Menopause—Hot Flash Support (Nonhormonal)
Peri/postmenopausal adults with vasomotor symptoms who prefer nonhormonal options.
women’s-health
vasomotor
nonhormonal
reduce frequency/severity of hot flashes
support quality of life
Core stack
Soy isoflavones (genistein-rich)
B+
Form: standardized soy isoflavone extract
Dose: 50 mg genistein equivalents/day
With meals
8–12 weeks
Why: Systematic reviews show modest reductions in hot flashes; endorsed as an option by NAMS 2023.
Cautions
- Discuss with oncology team in estrogen-sensitive cancers
- May cause mild GI upset
Adjuncts
S-equol
C
Dose: 10–20 mg/day (often 10 mg BID)
With meals
Notes: May benefit non-equol producers; smaller evidence base than isoflavones.
Monitoring
- Daily hot flash diary
- Sleep quality
- Any breast symptoms—report to clinician