Migraine Prevention (adjuncts)
Adults with episodic migraine; coordinate with clinician.
neurology
headache
reduce attack frequency/days
improve quality of life
Core stack
Magnesium (citrate/glycinate)
B
Dose: 400–600 mg elemental/day
Divide BID with food
8–12 weeks before judging effect
Why: Recommended by headache societies; probable efficacy with good tolerability.
Riboflavin (Vitamin B2)
B
Dose: 400 mg/day
With food
12 weeks
Why: Mitochondrial support; reduced migraine days in several RCTs.
Coenzyme Q10
C
Dose: 100–300 mg/day
Split BID/TID with fat-containing meals
12 weeks
Why: Some trials suggest decreased frequency; overall evidence modest.
Not recommended
- Butterbur (unpurified): Hepatotoxic PA compounds unless PA-free Rx-grade; many regions advise against.
Monitoring
- Monthly migraine days
- Acute med use