PCOS – metabolic and ovulatory support
Individuals with PCOS (diagnosed per guidelines), especially with insulin resistance/ovulatory dysfunction.
women
endocrine
metabolic
pcos
Support insulin sensitivity
Support ovulation/cycle regularity
Core stack
Myo-inositol
B
Form: powder/sachets
Dose: 2 g twice daily (total 4 g/day), often with 200 µg folic acid twice daily
morning and evening
3–6 months, then reassess
Why: Syntheses for the 2023 PCOS guideline: can be considered for metabolic and cycle outcomes; moderate/uneven evidence quality.
Cautions
- Pregnancy: recent RCTs in pregnant PCOS did not reduce complications — use per indication before pregnancy
- Avoid high-dose D-chiro-inositol monotherapy (potential adverse oocyte effects at high doses)
Adjuncts
Omega-3 fatty acids (EPA+DHA)
C
Dose: 1–2 g/day EPA+DHA
Vitamin D (if deficient)
C
Dose: per 25(OH)D status (commonly 1000–2000 IU/day)
Not recommended
- Various ‘fertility boosters’ without RCT backing: Lack of quality evidence and potential interactions.
Monitoring
- Cycle/ovulation (LH tests/BBT), HOMA-IR/fasting glucose
- Pregnancy — follow clinician guidance and routine labs