Premenstrual syndrome (PMS) – symptom relief
Menstruating individuals with PMS after other causes ruled out.
women
hormonal
Reduce somatic and mood symptoms
Improve function in the luteal phase
Core stack
Chaste tree berry (Vitex agnus-castus, standardized extract)
B
Form: standardized extract (e.g., Ze 440)
Dose: 20–40 mg/day for 3 cycles
daily
at least 3 cycles, then reassess
Why: RCTs (incl. BMJ) and reviews show reduction of PMS symptoms vs placebo.
Cautions
- Theoretical hormonal interactions — caution with HRT/contraceptives
- Avoid in pregnancy and lactation
Vitamin B6 (pyridoxine)
C
Form: tablets
Dose: 50–100 mg/day in the luteal phase or daily (short-term)
with food
2–3 cycles, then pause and reassess
Why: Older meta-analyses suggest moderate benefit, but overall evidence quality is limited.
Cautions
- Do not exceed 100 mg/day long-term (neuropathy risk)
Not recommended
- Complex herbal blends with undocumented composition: Lack of quality RCTs; variable product quality.
Monitoring
- PMS symptom diary each cycle
- Monitor B6 adverse effects