Glycemic Support (Prediabetes/T2D adjunct)
Adults with elevated fasting glucose/HbA1c (prediabetes or T2D) as adjuncts to lifestyle and medical care.
metabolic-health
blood-sugar
fiber
modestly reduce fasting glucose and HbA1c
improve post-meal glycemic response
Core stack
Berberine
A-
Form: berberine HCl
Dose: 500–1500 mg/day (in 2–3 divided doses)
With meals
12 weeks, then check labs
Why: Multiple RCT meta-analyses show reductions in HbA1c and fasting glucose vs placebo and additive effects with standard care.
Cautions
- GI upset common
- Potential interactions (e.g., calcineurin inhibitors, CYP substrates)
- Avoid in pregnancy/lactation
Psyllium (soluble fiber)
A-
Form: powder
Dose: 5–10 g before meals (2–3×/day)
10–15 minutes before meals with ≥250 ml water
8–12 weeks minimum
Why: GRADE-assessed meta-analyses show improvements in fasting glucose, HbA1c, and insulin sensitivity.
Cautions
- Take with ample water
- Separate from medications by ≥2 hours
Adjuncts
Protein preload (food-first)
C
Dose: 15–25 g protein 15–30 min pre–high-carb meal
Notes: Blunts post-prandial glucose via gastric emptying and incretin effects.
Monitoring
- Fasting glucose/HbA1c at baseline and 12 weeks
- GI tolerance
- Drug–supplement interactions